proband

Example:The proband was the index case of a rare genetic disorder that was later found to be inherited by family members.

Definition:The first or original case of a disease in a given population or family.

Example:Researchers used pedigree analysis to determine the inheritance pattern of the genetic disorder in the family of the proband.

Definition:The study of family relationships and the distribution of genetic traits within a family.

Example:The proband's genetic linkage studies helped identify the specific genes involved in the inheritance of the disease.

Definition:The tendency of genes or genetic markers to be inherited together due to their close physical proximity on the same chromosome.