decompensate

Example:This patient's renal function has now decompensated after switching to a new antihypertensive medication.

Definition:A state where the body's response to a drug is no longer effectively managed and shows signs of disease progression.

Example:The patient's cardiac decompensation required immediate medical intervention to stabilize his condition.

Definition:An exacerbation of heart disease that leads to a loss of compensatory mechanisms, often resulting in symptoms such as dyspnea, fatigue, and edema.

Example:The biochemical decompensation of the liver in a patient with cirrhosis can lead to hepatic encephalopathy.

Definition:A loss of homeostasis at the cellular or biochemical level that leads to the progression of a disease or disorder.