estrange

Example:The company's management decisions alienated many of its employees.

Definition:to cause someone to lose their affection, respect, or interest in someone or something

Example:Repeated betrayals have distanced him from his friends.

Definition:to make a person feel remote or separate from another person or a situation

Example:The bitter divorce detached him from his wife and children.

Definition:to cause a person to become less emotionally or mentally attached to someone or something